• WARNING: Tube/Valve amplifiers use potentially LETHAL HIGH VOLTAGES.
    Building, troubleshooting and testing of these amplifiers should only be
    performed by someone who is thoroughly familiar with
    the safety precautions around high voltages.

MosFET or other semiconductor substitute for cathodyne?

They do. For a PNP or PMOS you need to run the preceding tube anode at ~ 2/3 B+ instead of 1/3 B+ which can allow them to run at a better operating point sometimes.
Oh yeah, that's actually true. :)

This also leaves an interesting practical choice.
Because in some cases a quite high anode resistor needs to be used, otherwise a DC coupled cathodyne just doesn't work very well.

With a PNP, this works exactly the other way around! :)
So a lot less issues with nipple distortion! :) ;) ©

It will be hard to find a PMOS that will play nice around 250-350V
 
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These days, I usually slap in a capacitance multiplier with a Mosfet on the B+ anyway.
Since it costs bugger all, is super easy to implement and will just make the ripple go away completely.

But I had a couple of occasions that I couldn't use the DC follower because the anode resistor was getting to big.
In general with a 12AX7/ECC83, you need at least above 150kOhm to make that work.
So in that case it would work without a problem with a PNP

I think a cathodyne is quite need, since the distortion is very low, so the sonic impact is also very low.
 
The cap multiplier….Makes ripple go away completely - and gets rid of pesky low frequency feedback paths through the supply. And if regulated (or semi regulated) the decoupling and bypass caps downstream only need to be rated for the reduced supply, not the full unloaded voltage. That can be a big deal.

PNPs do solve the problem of needing to elevate the heaters. It just doesn’t have one. Neither do N channels, but they’re typically under 100V on the source/emitter/cathode.