PC Hum/HDD noise into preamplifier

If the DAC had no USB isolation and single-ended outputs were used, the ground loop currents would still go from the PC USB ground -> USB cable ground wire -> DAC (here partly back to the PC because the DAC is class I) -> class I amp through the signal interconnect -> amp PE wire -> PC PE wire. Noise around USB port ground will be different though.
 
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Well, Gustard x16 installed. Total silence from optical and USB, with the soundcard removed. Vastly improved sound from anything I play.
Have sent the card back to the supplier for repair/replacement, hopefully will get a new one in box I can sell since it's only a few months old. Thankyou for all the help.