• WARNING: Tube/Valve amplifiers use potentially LETHAL HIGH VOLTAGES.
    Building, troubleshooting and testing of these amplifiers should only be
    performed by someone who is thoroughly familiar with
    the safety precautions around high voltages.

How hard do you drive your 6c45?

I'm not currently using one but have played around with one and a colleague has used it for many years. The thing that I would be looking at is more 'subjective sound' than about power dissipation vs life. There are people who have used these tubes and found them a little harsh. I've had more experience with it's brother, the 6E5P tetrode which when triode-wired is a similar beast. it seems that a number of users have found that the subjective sound is not optimal at all currents and you may want to keep some flexibility in your design in case there is a sweet spot for your implementation. And I don't think it's all about harsh = parasitic oscillations, it's more than that.
 
100k as anode load??? 😳

6C45P output impedance is 1155R, so even 5k load is perfect.

If you see the tube curves and knows the desired anode swing, the operating point easy to select.
For maximizing the output swing (VAS stage) the choosable anode range is limited, about between 10-30mA.

6C45P curve.jpg
 
As a gain stage 150V anode 20mA works quite well in my experience. I’d use a cascode depleteion mode mosfet CCS as a load. I have used a 70H choke and like the CCS load better. Diodes for cathode bias, between 1.5 to 2V. I’ve also run them at 175V 40mA in a PO class A spud and they sound wonderful there too.