The Biology and Immunology Corner

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And yes, Tylenol overdose is tricky because you don't feel much sick for a couple days, and then you die. But 16 of the 500 is right up there, far beyond the max recommended.

I know and there is nothing stopping anybody from going to multiple shops.
On the up side it is dirt cheap. At Aldi a pack of 16 costs all of £0.27.

Mind you at Sainsbury's the same costs £1!
 
I don't really understand this fixation on Tylenol/Paracetamol/acetaminophen.

Several of my doctors over the years have recommended against taking acetaminophen to control fever, saying that it is far better to let the fever run its course. It is our body's way of creating a very unwelcome host environment. Obviously, if the fever goes high enough that there is a real risk of convulsions and/or brain damage, then you need to control the fever, but just popping 500mg tabs of that stuff at the first sign of being a bit warm is a terrible idea.
 
I don't really understand this fixation on Tylenol/Paracetamol/acetaminophen.

Several of my doctors over the years have recommended against taking acetaminophen to control fever, saying that it is far better to let the fever run its course. It is our body's way of creating a very unwelcome host environment. Obviously, if the fever goes high enough that there is a real risk of convulsions and/or brain damage, then you need to control the fever, but just popping 500mg tabs of that stuff at the first sign of being a bit warm is a terrible idea.

I don't really use it myself, but I rarely get headaches. I use NSAIDs for injuries / inflammation and, like you said, don't really see the need to get rid of a low fever.
 
I don't really understand this fixation on Tylenol/Paracetamol/acetaminophen.

Several of my doctors over the years have recommended against taking acetaminophen to control fever, saying that it is far better to let the fever run its course. It is our body's way of creating a very unwelcome host environment. Obviously, if the fever goes high enough that there is a real risk of convulsions and/or brain damage, then you need to control the fever, but just popping 500mg tabs of that stuff at the first sign of being a bit warm is a terrible idea.

I seem to remember learning that the elevated temperature of a fever makes it difficult for the virus to replicate. I think it helps with the immune response too.
I've always just knocked back a few pills if I feel feverish but you may be on to something...
 
There may some truth to that, but I have always had better luck following the advice of our family doctor from years ago who always recommended taking everything to make you get a better night's sleep and being better rested to help your body fight the sickness.
 
I don't really understand this fixation on Tylenol/Paracetamol/acetaminophen.

Several of my doctors over the years have recommended against taking acetaminophen to control fever, saying that it is far better to let the fever run its course. It is our body's way of creating a very unwelcome host environment. Obviously, if the fever goes high enough that there is a real risk of convulsions and/or brain damage, then you need to control the fever, but just popping 500mg tabs of that stuff at the first sign of being a bit warm is a terrible idea.

Both my daughters went over 40ºc, I gave them paracetamol at 40.6º and 41.2ºc respectively. Fever runs really high, and for a long time Several days at or just below 40º.
 
I seem to remember learning that the elevated temperature of a fever makes it difficult for the virus to replicate. I think it helps with the immune response too.
I've always just knocked back a few pills if I feel feverish but you may be on to something...
I've found paracetamol useless for aches and pains and don't use it anymore. I'd rather suffer higher temperatures while the body fights viruses if possible and recover sooner. Having asthma, I avoid NSAIDs.
 
well it's really surreal what is selling out in the shops. I went out to my local Budgens to get some bread flour as they do a nice locally grown mix with seeds n stuff in. All bread flour cleaned out, along with full fat milk, long life OJ and tinned carrots!


Ah well, white bread with linseeds and sesame seeds for us tonight then!
 
I am hoping Sean pops in here to help with this one. We know that sufficient heat is effective in breaking down the virus and that:

Soap or detergent assists in breaking down the lipids, should one do anything differently if hot water is not available? Should we wash for a longer period or use more soap or...?

TIA for your insight. You been a huge bonus in this most troubling time.
 
I don't really understand this fixation on Tylenol/Paracetamol/acetaminophen.

Because the French health minister has warned strongly against using ibuprofen, aspirin diclofenac and steroids but said that paracetamol is ok.

My daughter generally agreed since paracetamol works differently than the others to achieve similar goal.

I also heard suggestions that the relatively high death rate in Italy could be related to ibuprofen use to control temperature.
 
After a few weeks of lock down, then what ?

As soon as you remove the lockdown it will just come back to infect those not yet exposed. How long will everyone be willing to lose jobs, see bankruptcies, lack education, over worked health care folk and ballooning government debt before there’s a vaccine ??

The goal is to "flatten the curve" so we don't overwhelm our health care systems. We are witnessing this tragedy in Italy, where they have to triage patients and effectively "choose who lives". I don't think anyone believes we will eradicate this virus with lockdowns - just slow it down so it is manageable and thereby minimize unnecessary deaths.

This is a marathon, not a sprint.
 
After a few weeks of lock down, then what ?

As soon as you remove the lockdown it will just come back to infect those not yet exposed. How long will everyone be willing to lose jobs, see bankruptcies, lack education, over worked health care folk and ballooning government debt before there’s a vaccine ??

Lockdown does not decrease the number of those finally infected, it increases the numbers of those who can kept alive by our various health services.

I think we mostly agreed that Germany's death rate is exceptionally low because they have a shedload of ICUs and haven't reached capacity just yet.
 
Well I've just started reading the imperial uni models on this. https://www.imperial.ac.uk/media/im...-College-COVID19-NPI-modelling-16-03-2020.pdf Which I think has been posted before in a previous form. Makes kind of stark reading. Either we accept 250k deaths in uk or stay at home until there is a vaccine.

But then that implies >3.5 million deaths in China, who are ahead of UK. Not happened yet....

Oh - and yes - bread flour seems to be out everywhere! Weird...
 
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