Some tips that work for my rudimentary level of expertise:
-constrain the frequency range that you want the optimizer to work on; run it over and over in little chunks
-do one driver at a time (disconnect the earth on the other drivers)
-get the main curve done manually (by tweaking the values yourself) to get somewhat close to the target curve, then run the optimizer after
-you can micro manage the optimization in steps by turning components in one part of the filter optimization on or off (select it then press CTRL + Q or CTRL + E), e.g. leave a cap and coil on and run the optimizer, but disable it from running on the notch circuit, then turn the main filter optimization off and turn the notch back on, run the optimizer again
-in the bottom left you can set min and max values for parts so they don't waste time trying to evaluate silly values, e.g. set minimum on a resistor to 0.5ohm, set the min-max on a cap from (whatever) to 300uf, unless you want to pay loads of money for massive caps
-you can check "min impedance" higher than you'd be OK with, e.g. 8 ohms, just so it doesn't allow results below 1ohm, for example- it will still dip below 8 to meet the curve, but it won't allow nutso values
-checking "min phase" seems to do some phase alignment as part of the optimization
-you can set the number of optimizations to 200 or so, just so it doesn't spend time redundantly trying to optimize something to 0.1 of a value
-you can set rounding to E12 so it sticks to parts you can buy
hope this helps
