• WARNING: Tube/Valve amplifiers use potentially LETHAL HIGH VOLTAGES.
    Building, troubleshooting and testing of these amplifiers should only be
    performed by someone who is thoroughly familiar with
    the safety precautions around high voltages.

Why not a hobbyist topology?

A fellow where I used to work is/was a brilliant circuit designer. Power supply group. EE education in Russia. I asked him if he did any audio circuits in his EE training curriculum, specifically power tube output stages. He said the only one they analyzed the theory of, was a resistive loaded plate capacitively coupled to an OPT.

I remember some hype around using PA line distribution transformers as an OPT for a single ended design. Cheap and readily available. But, no gap to allow it to handle the DC bias, as when designed, they werent expecting a DC bias.

So, what aspect of a resistive loaded, capacitively coupled to an OPT output stage is so bad, that you never see it (?) as a viable single ended design? Is it because you lose efficiency; a 10W SE amp done with the "right" gapped OPT becomes only 5 with the scheme?

So what? Low power tube amps for guitar seem to be popular; perhaps its possible to get that SE tone without having to spend $150 on an OPT designed to work in that circuit. Just move the mic a little closer to the speaker.
 
Well, for one thing, a 400VDC supply suddenly needs to be a 600-800VDC supply. ;-) To change the load (say from 2.5K to 5K) you have to redesign the whole power supply. My Williamson amplifiers would need an 850VDC supply instead of 450VDC. You're throwing away a lot of heat and power.
 
"Try to do a quick design using a common 6BQ5/EL84 with 300v on the plate and biased to 50mA with a 5K load. What plate load resistor value would you use, and what primary Z for the OPT would you use? What PS B+ would you start with?"

OK, simple design - use a 10K resistor and a 10K transformer, to get a net 5K load. Then you get half the power and the resistor gets the other half. And you need another 500 volts, for a total 800v power supply.
 
Why would you need that kind of voltage if you only wanted a couple of miserable watts?
70 volt transformers aren’t a 5k load, even at 5 watts. Load impedance go down, voltage requirements go down with them. The problem is then a 6BQ5 is not the right tube. Need something that can swing more current on a 250-300V power supply, to match the needed 1k plate load. It’s a job for a big fat sweep tube. Some of them can be had for cheap, just like the transformer.