• WARNING: Tube/Valve amplifiers use potentially LETHAL HIGH VOLTAGES.
    Building, troubleshooting and testing of these amplifiers should only be
    performed by someone who is thoroughly familiar with
    the safety precautions around high voltages.

tube amps blow fuse?

Wouldn't it make sense to remove all of the tubes, replace the fuse, and power it up? (cut in half troubleshooting)
It doesn't make sense to me as a technican.
Why?
Because some tube amps/equipment have solid state rectifiers that if powered up without any loading can inject high peak DC voltages into the main filter capacitors.
And if those capacitors are stressed by the over-voltage now on them, can heat up, leak, and worst case, explode.
It's bad enough when working on tube equipment that strict safety proedures are followed, and someone not familier with them can be prone to being hurt.

Proper troubleshooting procedures require proper tools/testing equipment, and enough experience to carry out procedures in a safe way.
 
My DIY tube monoblock blew its fuse once with a loud bang. This was during operation, not at turning on. It took the mains interrupter at the house distribution table too. It had been working well for a couple of weeks before.
I carefully checked everything: cabling, tubes, filter capacitors, but did not find anything. Then I turned it on using a 100W lamp in series with the mains, no issue found. It has been working fine since then.