Tips on component layout in chassis

This is my first time trying to layout components onto an aluminum board, which I will CNC myself.

I'm interesting in what tips, rule of thumbs, etc, do others use when laying out components to be mounted to an aluminum plate.

In this particular case I'm laying out a modified version of Matt Renaud's Universal S4 pre-amp. I've added a DC regulator for the 12A*7 heaters and a cathode follower with a switch between it and gain. I now have more stuff than the original and need to modify the layout.

Thanks,
 
Hi rayma,

Yes, this is point to point. I guess I'm not really looking for direct suggestions on this particular build, but more of just general guidelines. Maybe there aren't any and it is more of an art form to lay out components.

I have started with graph paper to get approximate positioning, but will finish with building it all out in Fusion360. I'm going to need the G code for the CNC anyways.
 
In general, use the schematic, if it's a good one, as a rough placement guide, subject to change
make approximate pcb or base plate outline, changing as needed
place in/out/ps connectors, keeping the inputs away from outputs and noise sources
then place major/large components
then place power supply connections to major/large components
then remaining minor/small components and connections
then revise as needed, usually several times, to keep connections direct and to avoid interference
 
Thanks for the advice. I'm curious about keeping inputs from outputs. It makes sense to keep shield anything along the audio path from noise, but I've seen a lot of pre-amps were inputs and outputs are very close together. Why keep them apart?