A 10" 3-way + sub would be my "no compromise" speaker. There's always compromises, but this is what I would gravitate towards.
If using a sub and a 10" midbass I'd be looking at either a 3" or 4" full range or coax to get a decent point source at xo. (I've got some kef uniQ to try at some point)
Cheers,
Rob.