The Biology and Immunology Corner

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We just got case #1 in my county. It was detected today at the Ballad Health drive through test setup near the hospital in Johnson City.

"...the patient is in self-isolation and recently traveled out of the country."

Hydroxychloroquine is used to treat Rheumatoid Arthritis. I wonder if being on a maintenance dose of it would prevent a person from getting the virus?
 
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when a plane or a boat is planned to get back travellers at home from another continent or country with lower hygenic : maybe we should stop t get them back for this boomerang effects. Illness has no frontiers, so maybe each State could pay back eac other states to manage the turists than they don't get it from one month. Medical cares pay back already exist between many countries. But we could act that the countries feed and hostel each others turist then manage the pay back after ? Just an idea, maybe bad I dunno, at least an idea 😱


When you look at the infection maps it is clear than the most infected areas are also where we travel the most, whatever the travel because density (visit family, business, turism) : the denser the place the huger the transmission rate due to population density I believe basicly.
 
I readed each time there is an epidemic episode there are also some doctors than claim Chloroquine is the mollecul. At least not if unmixed for efficienty from what I noticed from a newspaper (needs to be mixed ?). In France a professor guy from an hspital said it was a good idea, but all the others specialists from the others areas say in vivo, it's not as easy as he claimed and more a bad idea. Maybe there will be an half-half till someone find a vaccin. For the moment Sean here and others virologists say it is relatvly a stable virus (few variations not big mutations) as they share the sequencing.


To try to slow the mutation if I understood comments, you must avoid at max the transmissions, that's why eveyone ask for confinment. I talked about 45 days/6 weeks before in a post, it looks like some countrys go towards that model to help, following Italy and China's experience. I'm not sure what Sean said about bounce effect and a possible covid20 -21 as he pointed out. But the most we can avoid the boomerang effect, the better to stop the virus changes before a mutation. So let sucess the vaccin to come (1 year more or less). It's also my understanding we can till act for liiting the spead... ask huge multi lateral origanisation though...
 
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I have to agree in that I also believe the mortality rate wont necessarily stay low (ish)

I'm a little worried that we (UK) havent been slightly more draconian in our mitigation efforts - folks just aren't heeding the government's request to stay in, away from crowds, pubs etc.

Meanwhile, my partner has a cough and it isnt continuous, no fever, so I am a bit lost whether I should be calling in work and isolating for 14 days, for fear of jumping too quickly and taking time off that I may need later

If there's any doubt, there is no doubt. Take off. 1 additional spreader in the USA was modeled to contribute 85 deaths in a matter of a few months. If this is indeed over in a few months... that'd be great. Unlikely, though if we can get over the hump survivability will skyrocket.
 
Important to note that mortality arising from the 1918 influenza epidemic arose from secondary infections.

Chart of some French research: source: https://www.mediterranee-infection....2020/03/Hydroxychloroquine_final_DOI_IJAA.pdf

A video I linked to earlier explains why and how hydroxychloroquine works and it is not by fighting secondary infections.

Hydroxychloroquine opens up path ways for zinc to enter our cells and it is that zinc which interrupts/hinders the virus' mRNA being copied.

Here it is again: YouTube

I recommend this one too:

YouTube

The channel and website was originally intended to help med students.
Here is a link MedCram - Medical Lectures Explained Clearly

Seems legit to me... 😉
 
On a positive note, we can be thankful doctors who work with infectious diseases are not as scary looking as they once were...
 

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Important to note that mortality arising from the 1918 influenza epidemic arose from secondary infections.

Chart of some French research: source: https://www.mediterranee-infection....2020/03/Hydroxychloroquine_final_DOI_IJAA.pdf


Jackinj, D Raoult is the guy under critics I talked about : seems there was a methodology problem in a part of hi claims about chloroquin in this particular virus, at least this what are thinking some more specilised french guys professor/scientists from different places, Pasteur and others big cities research hospitals... the guy would be a free electronic particle... though he is a part of a national comitee to advise. Maybe the pdf is not acurate in that particular context becaause the side effects, duno ?!..
 
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I think what he meant was a test to find out who had been infected and recovered and now had 'some' immune response who could be allowed out! Measuring the herd immunity so to speak.

Someone in Netherlands had an idea: there's literally 1000-s of people that daily give blood at the bloodbank. Why not check the samples for Corona antibodies? That way we can get a better view of how many have been infected and build up immunity.

Jan
 
Someone in Netherlands had an idea: there's literally 1000-s of people that daily give blood at the bloodbank. Why not check the samples for Corona antibodies? That way we can get a better view of how many have been infected and build up immunity.

Jan


Can we already check Corona 19 antibodies signature by a blood analysis ?


Btw, good to repeat that medicals are lacking of blood due to the outbreak. Giving one's blood is on the list on the allowed acts during the confinment (if your country has alread totally locked-down). There is protocols to protect the medical doctors by astronaut sort of suits and distance protocol between givers to allow you to give one's blood these days. They say the virus is not enough in the blood or not again but if you are very ill (so hospiltal phase). Also the blood are warmed after.
 
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