Seal inside of subwoofer?

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Hello everyone
I was wondering if I should primer or seal the inside of my subwoofer I'm building. I'm constructing it out of .75" mdf and plan on sealing the outside of the box. I want this sub to last a long time and am concerned how moister will affect the mdf. Any information will be greatly apprechiated.
If I should seal the inside, what should I seal it with?
 
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