New Build 2-way Driver selection advice sought.

The enclosure alone will run into several thousand dollars.
Dayton Audio DC130B-4

for such an expensive enclosure i would definitely not go with cheap drivers.
I would buy several different drivers, mount them in test enclosures to measure, tweak, optimize and listen to them.
at some future date will be 3-way
i suppose you will be adding a big woofer for low end? this absolutely makes sense and, if you accept lack of bass capability for the 2-way, would give you more options for dedicated (low-)midrange drivers.