DS1807 for guitar pot, loud buzzing

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I have a DS1807 chip being controlled by an Arduino and a mechanical pot. The circuit is working and the chip is reporting back the correct wiper positions.

However, when I connect any of the digipot pins to the output of either pickup in the guitar, I get a loud hum. Sounds like a ground issue, but much louder. The guitar has active pickups. I've tried powering the Arduino from different sources and still get the same result.

Any ideas why? I can post a wiring diagram if needed.

DS1807 datasheet:
http://datasheets.maximintegrated.com/en/ds/DS1807.pdf
 
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