SMPS-PWM design with bipolar supplies

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When making an SMPS supply using a PWM controller IC and two NFETs for switching, many of the topologies use a high-side driver to drive the upper FET, and the low-side FET is referenced to ground; this assumes that the ouptut voltage needed is positive.

What solution is there if a negative output voltage is needed for high power designs? Is there such a thing as a PWM controller for negative voltages, while still using NFETs?
 
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