different ohms on left and right channels?

I have here an Alpine PDX 2.150. It can run 2 ohms.

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can i run the left channel at 2 ohms and the right channel at 4 ohms, will it kill the amp?

Sorry clueless about electronics. I want to run a mono signal to both channels and use one channel for a sub, and the other channel for two 8 ohm speakers in series.