IBIS to SPICE

Ibis models the i/o portions, of otherwise digital chips. ive used ibis for pcb design transmission line simulation
and signal integrity (SI). We used hyperlynx software to do pcb SI sim based on pcb stack up and materials. Xilinx and other semi vendors provided the ibis models. You even get ibis models for memories, ASICS etc. FPGAs and ASICS have multiple I/O types that get chosen for the app, such as unipolar or differential, current mode(pecl), totem pole. open drain etc. Hyperlynx is now supported by siemens that bought Mentor Graphics.
https://eda.sw.siemens.com/en-US/pcb/hyperlynx/
I used this method 20 years ago, how time flys
 
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More like a virtual tdr type of measurement. simulate what you would see on a scope with a logic level change using selected cells. Check for Ringing from reflections from the load and disturbances on the transmission line if they are modeled. Eye diagrams can be done. Launch a voltage step response representing your source and model the transmission line effects with loads.