How to make the most of my equipment

I have a 2012 Jeep grand cherokee..
Head unit: JVC KDSR86BT
Door speakers: Cheap metra replacement 6x9 (work better off head unit than my kickers did)
Tweeters: skar tws-01
Sub/amp: Power Acoustik Razor2500.1d(750x1 at 2 ohm and 450 at 4ohm) Polk DB+ 10inch 350W rms in a Kicker CompC 10inch truck enclosure tuned to 34hz.

What settings and such would yall recommend I start as a baseline to make the most out of my equipment?