Instrumentation amplifier

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The caps are needed because all the opamp pins (input and output) are biased to half supply. So you need to ensure that whatever you connect to the input doesn't change that DC value... hence the cap. The output is AC coupled to 'remove' the 7.5 volts and just allow the AC signal through.

I can't think of any one specific document that explains that, its just general circuit theory and practice.
 
So is this some school/college project... just so we know 🙂

amplify signal of mv to +5V, with high accuracy, stability and sensitivity

That bit doesn't make sense. To take a varying input signal and process it to always get +5v output needs something different to a linear amplifier.
 
You've written 2.666 which is a low gain.

You also need to define what the expected type of input signal is. Is it AC, DC or both. Maximum and minimum frequencies it is expected to handle. Input impedance.
 
Well that's a really low gain which means any common opamp will work.

Next you have to decide whether the amp it to be inverting of overall phase or not, and then based on that calculate the basic value of the gain setting resistors.

Now you've shown that you can use LTspice so I'm not going to do all the hard work for you 😉 (and you won't learn anything)

Fig #1 in this document shows non inverting and figure #2 shows inverting. Calculate the resistor values you need and put them into a real (well a simulated) circuit and prove you have them correct.

http://www.ti.com/lit/an/slaa068a/slaa068a.pdf

If you get that far then we can look at refining it a bit further.
 
I tried this way also, but rather then becoming an amplifier it becomes voltage follower. I read some where with such low input voltage, op amps gives a max voltage of 3.5 and not more then that.

That circuit is OK but you don't at this stage need to add an offset to the input voltage. Your gain calculates out at exactly 2.666 and LT confirms that. If you divide the rms value of the output voltage by the input as shown by LT you get 2.66599

Opamps can give gains of many hundreds, many thousands even.
 
You see, you got it correct 🙂

Capture.JPG

Now you need to make it a real workable amplifier running on your single rail supply. Remember to use a reference voltage of half the supply and to AC couple the input.

Back later...
 
Do you want it to have an offset ?

If the amplifier is to amplify any offset present (because then the offset is a valid part of the signal) then it needs to be a DC coupled amp running on dual supplies.

If you want to ignore the offset then you need to AC couple the input (and then you can use the single supply).
 
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