That's really difficult to answer... its different for every speaker, every listening environment, every person's personal preference. Generally, on axis response (with the speaker pointed directly at you) could be considered more 'detailed' or brighter, but sometimes harsh. Off axis can be smoother at the sacrifice of detail. There is no right or wrong answer.
Your best bet is to start by playing some of your favorite music with only one speaker hooked up. Staying roughly at the level you will be seated at while listening, and move from being right in front to 4 feet to the right or left. listen to how the response changes as you move. If you like it with the speaker pointed at you, toe in your speakers to start. If you like it better when you're off to the side, start with the speakers pointing straight out. Once you have set up both speakers how you think will work best going off the first test with one speaker, start making adjustments to both to suit your needs. My WiBAQs sound best pointed straight out, since full range drivers sound better slightly off axis.