Guitar amp/cab build questions

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So I'm thinking of building my own cab (I've built subwoofers before so I can get the box tuned properly), but am wondering if I could use an effects box (e.g. boss 100t or similar) and a just a real 'vanilla' amplifier, if such a thing exists.
I guess I'm thinking if I drop $$ on a decent effects box, let it do it's thing and a really simple plate amp or something to drive the cab (PA amp maybe?).

Would it work?
 
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