Yes, of course such a thing is possible.
http://www.mif.pg.gda.pl/homepages/frank/sheets/030/t/TB2.5-400.pdf
This will need +Vg to work well, though.
Nonetheless, the fact that you had to ask whether you can make an SE amp from the TB2.5/500 shows that you don't have much experience with such things. Since the drive requirements will be fairly severe (basically a small power amp driving a bigger one, might I suggest to build the driver stage first as a stand alone amp, and you can tack on the high voltage output stage later
http://www.mif.pg.gda.pl/homepages/frank/sheets/030/t/TB2.5-400.pdf
This will need +Vg to work well, though.
Nonetheless, the fact that you had to ask whether you can make an SE amp from the TB2.5/500 shows that you don't have much experience with such things. Since the drive requirements will be fairly severe (basically a small power amp driving a bigger one, might I suggest to build the driver stage first as a stand alone amp, and you can tack on the high voltage output stage later
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