WARNING: Tube/Valve amplifiers use potentially LETHAL HIGH VOLTAGES.
Building, troubleshooting and testing of these amplifiers should only be
performed by someone who is thoroughly familiar with
the safety precautions around high voltages.
There may be a very tiny difference in hum performance between the two sections (for AC heaters), and a very tiny difference in internal capacitance. Unlikely to make any difference. The datasheet will help you.