Understanding "Voltage - Input Offset" Parameter

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What is the significance of the "Voltage - Input Offset" parameter for an op amp when used as a line stage or buffer amp?

For instance, the OPA134 is rated 500 µV and the LM4562 is rated at 100 µV. However, what does that mean for the typical topologies used for line amps and buffers?
 
Input offset voltage is the voltage you may have to provide (from a zero impedance source) to ensure that the opamp output voltage is zero. It could be argued that it is a measure of how well the input differential stage is balanced; this may or may not be of any real significance for audio purposes.

An opamp intended for DC use (e.g. in instrumentation) may have very low input offset voltage. This may, or may not, indicate that other aspects of behaviour more important for AC use have been compromised in order to achieve good DC performance.
 
For instance, the OPA134 is rated 500 µV

This means that if configured for a gain of 1 and DC coupled the output will have a worst case offset of 500uV. If configured with a gain of 10, the output offset will be 5000uV or 5mV.

Opamp offsets are specified as input referred. This is an irreducible apparent voltage between the input terminals. It's actually defined as the voltage you would need to apply to bring the output to zero. It enables you to calculate the likely offset at the output on the basis of the (DC) gain.
 
You have to remember that there are also input offset currents to be taken into consideration. Since these are generally supplied via the biassing and other resistors connected to the opamps inputs they develop a voltage across these resistances, and hence they will also contribute to any output offset voltage. If the resistances are very low, or the currents very low, as in the case of jfet input opamps, their contribution may be negligible, but they may also be significant.
 
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