John Curl's Blowtorch preamplifier part II

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Well my evening has been ruined (in a good way) by my boss putting me onto https://boomkat.com/ . There is stuff here that even Scott would find odd! Been sampling lots and some great stuff. For some reason very tempted to get the Daphne Oram CDs they have. Not something you would listen to regularly, but you have to go back to roots now and again :)

Hmmm really? It's amazing how many tiny independent labels there are and so much good stuff. ;) Of course one of the best is right here in Lowell MA, http://www.rrrecords.com/label-az.php . I've lost track of Byron Coley's lable but there's also http://www.importantrecords.com/
 
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Very, but it has some strong limitations because of varied biomes and genes. If I had one wish for the medical world right now it would be for editing genes in living people or to have some perfect cultures of bacteria to correct everyone's gut. That would require a few different versions for blood types, but still, the world could use that sorely.

I can't play anyone of those on my turntable however... which has been my obsession for a few weeks, finding vinyl.
 
Very, but it has some strong limitations because of varied biomes and genes. If I had one wish for the medical world right now it would be for editing genes in living people or to have some perfect cultures of bacteria to correct everyone's gut. That would require a few different versions for blood types, but still, the world could use that sorely.

1.) Editing living people's genes == uhhhhhhhhhh ethics? (and if you look at some of the immuno-targeting leukemia drugs, it's getting close to that)

2.) Translations of gut biome is good, but diversity is really really good. Most of us are much more okay with our guts than not. And it's not a risk-free offer, either.
 
2.) Translations of gut biome is good, but diversity is really really good. Most of us are much more okay with our guts than not. And it's not a risk-free offer, either.

Yes, many times people thought they understood all the science, or had all the facts, and rushed to action. Often there have been unexpected/unintended consequences. We don't seem to learn from experience as much as we should.

Sort of related, some people tend more to see things in terms of black and white, as opposed to more in terms of shades of grey. Someone's tendency in this respect, one way or the other, seems to be mostly a facet of personality. However, shades-of-grey people tend to be more accurate forecasters of the future, per Good Judgement Project research findings.
 
Black and white non-gray thinking is a bias that tends to be rooted in past trauma. IE a fight-or-flight response that has never fully deactivated. Thinking black-and-white about specific topics can often be addressed, but getting over the tendency to reduce things to black and white is often an enormously difficult task.
 
1.) Editing living people's genes == uhhhhhhhhhh ethics? (and if you look at some of the immuno-targeting leukemia drugs, it's getting close to that)

2.) Translations of gut biome is good, but diversity is really really good. Most of us are much more okay with our guts than not. And it's not a risk-free offer, either.

Obviously it would be preferable to not be able to edit by simple means, like air-born delivery. But for people with very bad genes it would help, and then it would help a lot on relief of the medical system - much of which working people subsidize.

We don't understand the gut biome worth a damn really. But it's actually not that complicated. For the most part our bodies will feed bacteria we co-exist with, by releasing a type of sugar into the intestines (it's based on our BT). But then we need lots of other interesting ones that process fiber correctly, all types, in order to make butyric acid. Some people don't have much of that ability, and that's a huge issue that has major health consequences. I'm making it sound complicated but the reality is if you could just basically get a diversity from about everyone with your same BT that is healthy, you'd be doing great. Even just getting a huge diversity from everyone that was healthy would be somewhat advisable. We tend to lose diversity due to drugs we take for infections... huge issue.

There was a documentary about Hitler's "crazy doctor" who cultured bacteria from many healthy soldiers and then introduced them to Hitler's gut. I'm not sure what the deliver was, but probably about the same as today (frozen doubled encapsulated pills). It cured all his digestive issues that were caused from bacterial death, ala chemical exposure, stress, treatments, etc, from earlier in his life. Now the documentary basically said this made the doctor that craziest SOB to ever live... a few years later from this documentary and this is the most cutting edge treatment we have that is restoring people's ability to live like a human. "Crazy" ? No, 70~ years ahead of his time genius.

But I'd prefer we have banks of healthy bacteria that we bread as opposed to having to collect from living individuals every time.
 
"Crazy" ? No, 70~ years ahead of his time genius. .

There was another doctor who noted that some people have pretty severe allergies. He noticed that cows didn't get hay fever, and hypothesized that there might be some factor in cow blood that protected them from the illness. To find out he injected a little cow blood into some human subjects. Of course, they didn't know about serum sickness then. The patients all died. Oh, well. They don't call him a genius because he guessed wrong, so he was obviously a fool. Or was he? When somebody else guesses right, there is a human tendency to attribute his accomplishment to genius, and ignore whatever role luck may have played. This tendency can be viewed as part of the broader cognitive bias known as the Halo Effect. Since there is much to the topic of Halo Effect, there is a whole book on the subject of it operating in just the business world, not to mention how it affects every other area of life when we attribute results associated with people to their character. Recommended reading: https://www.amazon.com/Halo-Effect-Business-Delusions-Managers/dp/1476784035
 
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Embarrassment of riches

Hmmm really? It's amazing how many tiny independent labels there are and so much good stuff. ;) Of course one of the best is right here in Lowell MA, RRRecords, Lowell, MA, USA . I've lost track of Byron Coley's lable but there's also Important Records

It's true, we have (in many cases immediate) access to artists directly. I've been a huge Kosmische Musik fan since the mid-70's, bands like Amon Duul II, Can, Ash Ra Tempel, etc., and these days I am buying remastered stuff directly from Manny Gottsching of Ash Ra himself. I love that he is getting a bigger share of the $, and DLing hi-res FLAC files has proven to be in many cases the best sounding transfer medium I have heard.

A few of my favorite labels are:
Recommended Records, run by Chris Cutler of Henry Cow fame (ReR Megacorp),
Seventh Records, mainly French Magma and related Zeuhl music (Seventhrecords)
Mellatronen from Sweden (Mellotronen.com)
Moonjune (MoonJune Records, NYC) Canterbury, jazz, rock
Cuneiform (http://cuneiformrecords.com/)

With these labels, the vast majority of the money goes directly to the artist.

Cheers!
Howie

Howard Hoyt
CE - WXYC-FM 89.3
UNC Chapel Hill, NC
diyAudio server HTTPS page
 
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I have Continental 4000S II 23mm (more like 25mm) and I love the way they grip,

My winter tires are too skinny, they are only 38mm, though they have tungsten carbide studs, which do a nice job on ice. I would prefer if they were more like 45mm, but my bike lacks clearance for sensible sized tires. After all, larger tires full of free air at lower pressure are the cheapest, easiest way to make your bicycle more comfortable, and when you are my age comfort keeps you on the bike more than imaginary yellow jerseys.

I might be able to fit a 40mm tire if I removed the fenders, but what is the point of a bicycle without fenders? Without fenders you can't ride comfortably in the wet, or slush or snow, so there's more than half the year gone. I need my bike to get to work and home again, I can't be a weekend ****** pretending to be a racer. Lack of adequate wheel clearance is my biggest gripe with most modern bicycles.
 
I have no problem finding vinyl. It's getting permission to buy it! Floor can't take much more :)

In the garage or the basement, man! I filled up an entire wall of our basement over about 10 years.
Then we moved after I retired, and now I have a music room on the ground floor filled with records,
and my audio equipment. It's our cultural duty to save them.
 
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There was another doctor who noted that some people have pretty severe allergies. He noticed that cows didn't get hay fever, and hypothesized that there might be some factor in cow blood that protected them from the illness. To find out he injected a little cow blood into some human subjects. Of course, they didn't know about serum sickness then. The patients all died. Oh, well. They don't call him a genius because he guessed wrong, so he was obviously a fool. Or was he? When somebody else guesses right, there is a human tendency to attribute his accomplishment to genius, and ignore whatever role luck may have played. This tendency can be viewed as part of the broader cognitive bias known as the Halo Effect. Since there is much to the topic of Halo Effect, there is a whole book on the subject of it operating in just the business world, not to mention how it affects every other area of life when we attribute results associated with people to their character. Recommended reading: https://www.amazon.com/Halo-Effect-Business-Delusions-Managers/dp/1476784035

That's not a comparrison, it's just stupid. Humans can eat every part of a cow. In fact if we could die from a sprinkle of cow blood that we ate we'd probably still be in the stone age if not even a species that was out-competed. There's just no relation to putting things into the tube that runs through us, and injecting directly into the blood. Our digestive tract we think of as "being inside of us" but it's really a highly controlled environment outside of us. This is why people begin to die when their digestive system is too compromised....

Seriously, children eat things all the time they shouldn't. We don't propose they're akin to injecting other species blood into our own bodies. I'm trying not to be too much of an ***, but it's just such a retarded comparrison.

Eating things is only second to topical application in safety, really. We're very tolerant unless we make scary stuff ourselves that exposure of any kind is threatening enough to be outright scary. Yes we might get "food poisining" but people survive trivial things like that daily... unless all the fast food and commercial food industry shut down without a noticing.
 
In the garage or the basement, man! I filled up an entire wall of our basement over about 10 years.
Then we moved after I retired, and now I have a music room on the ground floor filled with records,
and my audio equipment. It's our cultural duty to save them.

Damn straight because younger people like me need you to die leaving things behind in such a way that I can have access without them being tossed to the wind (or thrift store/dump).
 
That's not a comparrison, it's just stupid.

Sure, given what we know now, it was stupid. But we both told stories about doctors who tried experiments before they or anyone else knew what we know now. So, at the time they did it, both were taking unknown risks. And both probably thought their risks were small. One happened to be right and the other wrong.

Fast forward to the present. For the doctor who was right, we attribute his success to genius. For the doctor who was wrong, we attribute his failure to stupidity. But both attributions are cognitive errors due to bias of System 1 brain processes running in the background inside our heads right now.

To judge one doctor as genius and the other stupid is something done based on two things: (1) We are making a judgement of old, long gone doctors as though they were living today and know what doctors know today or at least only a little before today, and (2) we are assuming that what they did and their results are due to the type of person they are, some permanent aspect of their personalities that permeates and shapes everything they do. One is a genius, the other is stupid.

But, there is something we have neglected. Maybe one was very lucky in one experiment, and was often very stupid, and maybe the other was very unlucky in deciding to try an experiment that as it happened did not turn out well, but maybe many or most of the other things he did were pretty brilliant. However, we don't have any information about those things, or to tell us about what role luck played in the particular decisions we are now using to rate our assessment of them as genius or stupid. Given the lack of information, what do our human brains do? The function in a way that demonstrates the Halo Effect. We assume that character (genius, stupidity) is the cause of their respective success and failure, but we attribute nothing to luck or other unknown factors for the success or failure. This is a mistake. Luck usually play more of a role in important events than we realize, and character (genius, stupidity) plays less of a role than we tend to assume.
 
I'm sorry, you lost me here. Which way is it?

* Nothing is ever simple, even if models are able to reduce things well. This is infinitely more the case with biology. Mark's reasoned points here are worth tempering your view.

We don't understand it, but it's not that hard to improve out situation with it.

Sorry but Mark keeps going on when it's pointless. The doctor's approach was really not much more risky than eating a handful of dirt. Could something happen? Sure. But again if it was a big issue, children would never survive.
 
We don't understand it, but it's not that hard to improve out situation with it.

Sorry but Mark keeps going on when it's pointless. The doctor's approach was really not much more risky than eating a handful of dirt. Could something happen? Sure. But again if it was a big issue, children would never survive.

Okay, then please stay far away from anything medicine related. And make sure someone else thoroughly checks and signs off on the safety of your released equipment. It's way too reckless a mindset, IMO.
 
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Given the wobbly meat sacks that we are are 90% non-eukaryotic cells its safe to say we have a huge amount to work out about how the various symbiotic relationships inside us work. Or stop working. We are mobile cities for populations of organisms. Now, who are the clever ones in this?
 
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